2024
Amawi T, Nmarneh A, Noy G, Ghantous M, Niv MY, Di Pizio A, Priel A*. Identification of the TRPA1 cannabinoid-binding site. Pharmacological Research 2024; 209. doi.org/10.1016/j.phrs.2024.107444
Czech C, Lang T, Graßl A, Steuer A, Di Pizio A, Behrens M, Lang R. Identification of mozambioside roasting products and their bitter taste receptor activation. Food Chemistry 2024, 446, 138884. doi: 10.1016/j.foodchem.2024.138884
Di Pizio A*. A bitter taste receptor activated in a surprising way. Nature (News and Views) 2024. doi: 10.1038/d41586-024-00712-6
Dos Santos Natividade R, Dumitru AC, Nicoli A, Strebl M, Sutherland DM, Welsh OL, Ghulam M, Stehle T, Dermody TS, Di Pizio A*, Koehler M*, Alsteens D*. Viral capsid structural assembly governs the reovirus binding interface to NgR1. Nanoscale Horizons 2024; 9, 1925. doi.org/10.1039/d4nh00315b
Kogut-Günthel MM, Zara Z, Nicoli A, Steuer A, Lopez-Balastegui M, Selent J, Karanth S, Koehler M, Ciancetta A, Abiko LA, Hagn F, Di Pizio A*. The path to the G protein-coupled receptor structural landscape: Major milestones and future directions. British Journal of Oharmacology 2024, 1-24. doi.org/10.1111/bph.17314
Lopez-Balastegui M, Stepniewski TM, Koguut-Günthel MM, Di Pizio A, Rosenkilde MM, Mao J, Selent J. Relevance of G protein-coupled receptor (GPCR) dynamics for receptor activation, signalling bias and allosteric modulation. British Journal of Pharmacology 2024, 1-14. doi: 10.1111/bph.16495
Musiol E, Fromme T,Hau J, Di Pizio A, Klingenspor M. Comparative functional analysis reveals differential nucleotide sensitivity between human and mouse UCP1. ActaPhysiol 2024;00:e14209. doi:10.1111/apha.14209
Schaefer S, Ziegler F, Lang T, Steuer A, Di Pizio A, Behrens M. sweet-bound chemoreception of bitter bile acids and peptides is mediated by the same subset of bitter taste receptors. Cellular and Molecular Life Sciences 2024, 81 (1), 1-13. doi: 10.1007/s00018-024-05202-6
Scharf MM*, Humphrys L, Berndt L, Di Pizio A, Lehmann J, Liebscher I, Nicoli A, Niv M, Peri L, Schihada H, Schulte G. The dark sides of the GPCR tree - research progress on understudied GPCRs. British Journal of Pharmacology 2024. doi: 10.1111/bph.16325
Srivastava P, Steuer A, Ferri F, Nicoli A, Schultz K, Bej S, Di Pizio A*, Wolkenhauer O*. Bitter peptide prediction using graph neural networks. Journal of Cheminformatics 2024; 16, 111. doi.org/10.1186/s13321-024-00909-x
2023
Di Pizio A*, Bermudez M, De Graaf C, Jockers R*. Editorial: Peptide-binding GPCRs coming of age. Front. Endocrinol. - Cellular Endocrinology 2023. doi: 10.3389/fendo.2023.1189508
Lang T, Di Pizio A, Risso D, Drayna D, Behrens M*. Activation Profile of Tas2r2, The 26th Human Bitter Taste Receptor. Molecular Nutrition & Food Research 2023, 2200775. doi: 10.1002/mnfr.202200775
Morales P, Scharf MM, Johnson CP, Di Pizio A*, Hilger D*. Editorial: New approaches for the discovery of GPCR ligands. Front Endocrinol 2023, 14, 1272700. doi: 10.3389/fendo.2023.1272700
Nicoli A, Haag F, Marcinek P, He R, Kreißl J, Stein J, Marchetto A, Dunkel A, Hofmann T, Krautwurst D*, Di Pizio A*. Modeling the Orthosteric Binding Site of the G Protein-Coupled Odorant Receptor OR5K1, Journal of Chemical Information and Modeling 2023, 63(7), 2014. doi: 10.1021/acs.jcim.2c00752
Nicoli A, Weber V, Bon C, Steuer A, Gustincich S, Gainetdinov RR, Lang R, Espinoza S*, Di Pizio A*. Structure-Based Discovery of Mouse Trace Amine-Associated Receptor 5 Antagonists. J Chem Inf Model 2023. doi: 10.1021/acs.jcim.3c00755
Tiroch J, Dunkel A, Sterneder S, Teetner S, Behrens M, Di Pizio A, Ley JP, Lieder B, Somoza V*. Human Gingival Fibroblasts as a Novel Cell Model Describing the Association between Bitter Taste Thresholds and Interleukin-6 Release. Journal of Agricultural and Food Chemistry 2023. doi: 10.1021/acs.jafc.2c06979
Ziegler F, Steuer A, Di Pizio A, Behrens M*. Physiological Activation of Human and Mouse Bitter Taste Receptors by Bile Acids. Communications Biology 2023, 6, 612. doi: 10.1038/s42003-023-04971-3
2022
Adler Berke N, $ Di Pizio A,$ Vaden TD, Shoval I, Gover O, Waiger D, Solomon G, Sepčić K, Schwartz B*. Critical sites on ostreolysin A responsible for interaction with cytoskeletal proteins. Biomedicines 2022, 10(10), 2442. IF (2020): 4.8. doi: 10.3390/biomedicines10102442
De León G, Fröhlich E, Di Pizio A, Salar-Behzadi S* Premexotac: Bitterants in silico Screening using Machine Learning for Advancing Pharmaceutical Development. International Journal of Pharmaceutics 2022, 628, 122263. doi: 10.1016/j.ijpharm.2022.122263
Haag F, Di Pizio A, Krautwurst D*. The key food odorant receptive range of broadly tuned receptor OR2W1. Food Chemistry 2022, 375: 131680. IF (2020): 7.5. doi: 10.1016/j.foodchem.2021.131680
León B*, González G, Nicoli A, Rojas A, Di Pizio A, Ramirez-Carvajal L, Jiménez C. Phylogenetic and mutation analysis of the Venezuelan equine encephalitis virus sequence isolated in Costa Rica from a mare with encephalitis. Veterinary Sciences 2022, 9(6): 258. IF (2020): 2.3. doi: 10.3390/vetsci9060258
Nicoli A, Dunkel A, Giorgino T, De Graaf C, Di Pizio A*. Classification Model for the Second Extracellular Loop of Class A GPCRs, Journal of Chemical Information and Modeling 2022, 62(3): 511–522. IF (2020): 5. doi: 10.1021/acs.jcim.1c01056
2021
Agamennone M, Nicoli A, Bayer S, Weber V, Borro L, Gupta S, Fantacuzzi M, Di Pizio A*. Protein-protein interactions at a glance: Protocols for the visualization of biomolecular interactions. Methods in Cell Biology 2021, 166: 271-307, Part of volume: Biomolecular Interactions Part A, ISBN: 978-0-12-823351-1, edited by Arun K. Shukla. doi: 10.1016/bs.mcb.2021.06.012
Bayer S, Mayer AI, Borgonovo G, Morini G, Di Pizio A*, Bassoli A*. Chemoinformatics View on Bitter Taste Receptor Agonists in Food. Journal of Agricultural and Food Chemistry 2021, 69(46): 13916–13924. IF (2020): 5.3. doi: 10.1021/acs.jafc.1c05057
Behrens M*, Di Pizio A, Redel U, Meyerhof W*, Korsching SI*. At the root of T2R gene evolution: Recognition profiles of coelacanth and zebrafish bitter receptors. Genome Biology and Evolution 2021, 13(1): evaa264. IF (2020): 3.5. doi: 10.1093/gbe/evaa264
Cecchetto C, Di Pizio A, Genovese F, Calcinoni O, Macchi A, Dunkel A, Ohla K, Spinelli S, Farruggia MC, Joseph PV, Menini A, Cantone E, Dinnella C, Cecchini MP, D’Errico A, Mucignat-Caretta C, Parma V, Dibattista M*. Assessing the extent and timing of chemosensory impairments during COVID-19 pandemic. Scientific Reports 2021, 11, 17504. IF (2020): 4.0. doi: 10.1038/s41598-021-96987-0
Gerkin RC, …, Di Pizio A, …, Parma V. (GCCR) Recent smell loss is the best predictor of COVID-19 among individuals with recent respiratory symptoms. Chemical Senses 2021, IF (2020): 3.1. doi: 10.1093/chemse/bjaa081
Ofir-Birin Y, Pilo HBA, Camacho AC, Rudik A, Rivkin A, Revach O-Y, Nir N, Tamin TB, Karam PA, Kiper E, Peleg Y, Nevo R, Solomon A, Havkin-Solomon T, Rojas A, Rotkopf R, Porat Z, Avni D, Schwartz E, Zillinger T, Hartmann G, Di Pizio A, Quashie NB, Dikstein R, Gerlic M, Torrecilhas AC, Levy C, Bowie AG, Regev-Rudzki N*. Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration. Nature Communications 2021, 12, 4851. IF (2020): 14.9. | doi: 10.1038/s41467-021-24997-7
Sterneder S, Stoeger V, Dugulin CA, Liszt KI, Di Pizio A, Korntheuer K, Dunkel A, Eder R, Ley JP, Somoza V*. Astringent Gallic Acid in Red Wine Regulates Mechanisms of Gastric Acid Secretion via Activation of Bitter Taste Sensing Receptor TAS2R4. Journal of Agricultural and Food Chemistry 2021, 69(36): 10550–10561. IF (2020): 5.3. doi: 10.1021/acs.jafc.1c03061
Tiroch J, Sterneder S, Di Pizio A, Lieder B, Hoelz K, Holik A, Pignitter M, Behrens M, Somoza M, Ley JP, Somoza V*. Bitter Sensing TAS2R50 Mediates the trans-Resveratrol-Induced Anti-inflammatory Effect on Interleukin 6 Release in HGF-1 Cells in Culture. Journal of Agricultural and Food Chemistry 2021, 69(45): 13339–13349. IF (2020): 5.3. doi: 10.1021/acs.jafc.0c07058
2020
Cooper KW, Brann DH, Farruggia MC, Bhutani S, Pellegrino R, Tsukahara T, Weinreb C, Joseph PV, Larson ED, Parma V, Albers MW, Barlow LA*, Datta SR*, Di Pizio A*. COVID-19 and the chemical senses: supporting players take center stage. Neuron 2020, 107(2): 219-233. IF (2020): 17.2. doi: 10.1016/j.neuron.2020.06.032
Di Pizio A*, Nicoli A. In silico molecular study of tryptophan bitterness. Molecules 2020, 25(20): 4623-4632. IF (2020): 4.4. doi: 10.3390/molecules25204623
Di Pizio A, Behr J, Krautwurst D*. Towards the Digitalization of Olfaction, Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier, 2020. ISBN 9780128093245, doi: 10.1016/B978-0-12-809324-5.24147-3
Dunkel A, Hofmann T, Di Pizio A*. In-silico investigation of bitter hop-derived compounds and their cognate bitter taste receptors. Journal of Agricultural and Food Chemistry 2020, 68 (38): 10414-10423. IF (2020): 5.3. doi: 10.1021/acs.jafc.9b07863
Laghezza A, Piemontese L, Brunetti L, Caradonna A, Agamennone M, Di Pizio A, Pochetti G, Montanari R, Capelli D, Tauro M, Loiodice F, Tortorella P*. Bone-Seeking Matrix Metalloproteinase Inhibitors for the Treatment of Skeletal Malignancy. Pharmaceuticals 2020, 13(6): 113. IF (2020): 5.7. doi: 10.3390/ph13060113
Lang T, Lang R, Di Pizio A, Mittermeier VK, Schlagbauer V, Hofmann T, Behrens M. Numerous compounds orchestrate coffee’s bitterness. Journal of Agricultural and Food Chemistry 2020, 68 (24): 6692-6700. IF (2020): 5.3. doi: 10.1021/acs.jafc.0c01373
Leung N, Thakur DP, Gurav AS, Kim SH, Di Pizio A, Niv MY, Montell C*. Functions of Opsins in Drosophila Taste. Current Biology 2020, 30: 1-13. IF (2020): 10.83. doi: 10.1016/j.cub.2020.01.068
Parma V, …, Di Pizio A, …, Hayes JE (GCCR). More than smell - COVID-19 is associated with severe impairment of smell, taste, and chemesthesis. Chemical Senses 2020, 45(7), 609-62. IF (2020): 3.1. doi: 10.1093/chemse/bjaa041
Pellegrino R, Cooper KW, Di Pizio A, Joseph PV, Bhutani S, Parma V. Coronaviruses and the chemical senses: past, present, and future. Chemical Senses 2020, 45(6): 415–422. IF (2020): 3.1. doi: 10.1093/chemse/bjaa031
Sabir F*, Di Pizio A, Loureiro-Dias MC, Casini A, Soveral G, Prista C. Insights into the Selectivity Mechanisms of Grapevine NIP Aquaporins. International Journal of Molecular Sciences 2020, 21(18): 6697. IF (2020): 5.9. doi: 10.3390/ijms21186697
Spaggiari G, Di Pizio A*, Cozzini P*. Sweet, umami and bitter taste receptors: State of the Art of in silico molecular modelling approaches. Trends in food science & technology 2020, 96: 21-29. IF (2020): 12.6. doi: 10.1016/j.tifs.2019.12.002
2019
Arafeh R, Di Pizio A, Elkahloun AG, Dym O, Niv MY, Samuels Y*. RASA2 and NF1; two-negative regulators of Ras with complementary functions in melanoma. Oncogene 2019, 38(13): 2432-2434. IF (2019): 6.7. doi: 10.1038/s41388-018-0578-4
Dagan-Wiener A*, Di Pizio A, Nissim I, Bahia MS, Dubovski N, Margulis E, Niv MY*. BitterDB: taste ligands and receptors database in 2019. Nucleic Acids Research 2019, 47(D1): D1179-D1185. IF (2019): 11.2. doi: 10.1093/nar/gky974
Di Pizio A*, Behrens M, Krautwurst D. Beyond the flavour: the potential druggability of chemosensory GPCRs. International Journal of Molecular Sciences 2019, 20(6): 1402. IF (2019): 4.5. doi: 10.3390/ijms20061402
Di Pizio A, Waterloo L, Brox R, Löber S, Weikert D, Behrens M*, Gmeiner P*, Niv MY*. Rational design of agonists for bitter taste receptor TAS2R14: from modelling to bench and back. Cellular and Molecular Life Sciences 2020, 77: 531-542. IF (2019): 6.5. doi: 10.1007/s00018-019-03194-2
Laghezza A, Luisi G, Caradonna A, Di Pizio A, Piemontese L, Loiodice F, Agamennone M*, Tortorella P*. Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors. Bioorganic and Medicinal Chemistry 2019, 28(3): 115257. IF (2019): 2.8. doi: 10.1016/j.bmc.2019.115257
Qin C, Qin Z, Zhao D, Pan, Zhuang L, Wan H, Di Pizio A, Malach E, Niv MY, Huang L, Hu N, Wang P*. A bioinspired in vitro bioelectronic tongue with human T2R38 receptor for high-specificity detection of N-C=S-containing compounds. Talanta 2019, 199: 131-139. IF (2019): 4.9. doi: 10.1016/j.talanta.2019.02.021
Thawabteh A, Lelario F, Scrano L, Bufo SA, Nowak S, Di Pizio A, Niv MY, Behrens M, Karaman R*. Design, Synthesis and Functional studies of Bitterless Guaifenesin Prodrugs. Chemical Biology & Drug Design 2019, 93(3): 262-271. IF (2019): 2.4. doi: 10.1111/cbdd.13409
Wodak SJ*, Paci E, Dokholyan NV, Berezovsky IN, Horovitz A, Li J, Hilser VJ, Bahar I, Karanicolas J, Stock G, Hamm P, Stote RH, Eberhardt J, Chebaro Y, Dejaegere A, Cecchini M, Changeux J-P, Bolhuis PG, Vreede J, Faccioli P, Orioli S, Ravasio R, Yan L, Brito C, Wyart M, Gkeka P, Rivalta I, Palermo G, McCammon A, Panecka-Hofman J, Wade RC, Di Pizio A, Niv MY, Nussinov R, Tsai C-J, Jang H, Padhorny D, Kozakov D, McLeish T. Allostery in Its Many Disguises: From Theory to Applications. Structure 2019, 27: 566-578. IF (2019): 4.6. doi: 10.1016/j.str.2019.01.003
2018
Di Pizio A*, Agamennone M, Laghezza A, Loiodice F, Tortorella P. Mimic catechins to develop selective MMP-2 inhibitors. Monatshefte für Chemie - Chemical Monthly 2018, 149(7):1293-1300. IF (2018): 1.5. doi: 10.1039/c9md00165d
Di Pizio A, Ben Shoshan-Galeczki Y, Hayes JE, Niv MY*. Bitter and sweet tasting molecules: it's complicated. Neuroscience Letters 2018, 1(700): 56-63. IF (2018): 2.2. doi: 10.1016/j.neulet.2018.04.027
Nowak S, Di Pizio A, Levit A, Niv MY, Meyerhof W, Behrens M*. Reengineering the ligand sensitivity of the broadly tuned human bitter taste receptor TAS2R14. Biochimica et Biophysica Acta - General Subjects 2018, 1862(10): 2162-2173. IF (2018): 3.7. doi: 10.1016/j.bbagen.2018.07.009
2017
Cheled-Shoval S, Behrens M, Korb A, Di Pizio A, Meyerhof W, Uni Z, Niv MY*. From Cell to Beak: In-Vitro and In-Vivo Characterization of Chicken Bitter Taste Thresholds. Molecules 2017, 22(5): pii: E821. IF (2017): 3.1. doi: 10.3390/molecules22050821
Di Pizio A*, Kruetzfeldt LM, Cheled-Shoval S, Meyerhof W, Behrens M, Niv MY*. Ligand binding modes from low resolution GPCR models and mutagenesis: chicken bitter taste receptor as a test-case. Scientific Reports 2017, 7: 8223. IF (2017): 4.2. doi: 10.1038/s41598-017-08344-9
Di Pizio A*, Shy N, Behrens M, Meyerhof W, Niv MY. Molecular features underlying selectivity in chicken bitter taste receptors. Frontiers in Molecular Biosciences 2017, 5: 6. IF (2017): 3.6. doi: 10.3389/fmolb.2018.00006
Oren T, Nimri L, Yehuda-Shnaidman E, Staikin K, Hadar Y, Friedler A, Amartely H, Slutzki M, Di Pizio A, Niv MY, Perry I, Graeve L, Schwartz B*. Recombinant ostreolysin induces brown fat-like phenotype in HIB-1B cells. Molecular Nutrition & Food Research 2017, 61(9): 1-15. IF (2017): 5.2. doi: 10.1002/mnfr.201700057
Qutob N, Masuho I, Alon M, Emmanuel R, Cohen I, Di Pizio A, Madore J, Elkahloun A, Ziv T, Levy R, Gartner JJ, Hill VK, Lin JC, Hevroni Y, Hob P, Brodezki A, Rosenberg SA, Kosloff M, Hayward NK, Admon A, Niv MY, Scolyer RA, Martemyanov KA, Samuels Y*. RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells. Scientific Reports 2017, 8: 653. IF (2017): 4.2. doi: 10.1038/s41598-017-18851-4
Xue AY, Di Pizio A, Levit A, Yarnitzky T, Penn O, Pupko T, Niv MY*. Independent Evolution of Strychnine Recognition by Bitter Taste Receptor Subtypes. Frontiers in Molecular Biosciences 2017, 5: 9. IF (2017): 3.6. doi: 10.3389/fmolb.2018.00009
2016
Di Pizio A, Agamennone M, Tortorella P*. Non-zinc-binding inhibitors of MMP-13: GRID-based approaches to rationalize the binding process. Current Topics in Medicinal Chemistry 2016, 16(4): 449-59. IF (2016): 3.0, doi: 10.2174/1568026615666150813150631
Di Pizio A, Levit A, Slutzki M, Behrens M, Karaman R, Niv MY*. Comparing Class A GPCRs to bitter taste receptors: Structural motifs, ligand interactions and agonist-to-antagonist ratios. In G Protein-Coupled Receptors: Signaling, Trafficking and Regulation (Shukla, A. K., Ed.), pp. 401-427. Methods in cell biology 2016. IF (2016): 3.0, doi: 10.1016/bs.mcb.2015.10.005
Karaman R, Nowak S, Di Pizio A, Kitaneh H, Abu-Jaish A, Meyerhof W, Niv MY, Behrens M*. Probing the binding pocket of the broadly tuned human bitter taste receptor TAS2R14 by chemical modification of cognate agonists. Chemical Biology & Drug Design 2016, 88(1): 66-75. IF (2016): 2.4, doi: 10.1111/cbdd.12734
Tauro M, Laghezza A, Loiodice F, Piemontese L, Caradonna A, Capelli D, Montanari R, Pochetti G, Di Pizio A, Agamennone M, Campestre C, Tortorella P*. Catechol-based matrix metalloproteinase inhibitors with additional anti-oxidative activity. Journal of Enzyme Inhibition and Medicinal Chemistry 2016, 24: 1-13. IF (2016): 4.3, doi: 10.1080/14756366.2016.1217853
2015 und früher
Arafeh R, Qutob N, Emmanuel R, Keren-Paz A, Madore J, Elkahloun A, Wilmott JS, Gartner JJ, Di Pizio A, Winograd-Katz S, Sindiri S, Rotkopf R, Dutton-Regester K, Johansson P, Pritchard AL, Waddell N, Hill VK, Lin JC, Hevroni Y, Rosenberg SA, Khan J, Ben-Dor S, Niv MY, Ulitsky I, Mann GJ, Scolyer RA, Hayward NK, Samuels Y*. Recurrent inactivating RASA2 mutations in melanoma. Nature Genetics 2015, 47(12): 1408-10. IF (2015): 31.6. doi: 10.1038/ng.3427
Di Pizio A, Aschi M, Agamennone M*. An integrated computational approach to rationalize the activity of non-zinc-binding MMP-2 inhibitors. PLOS ONE 2012, 7(11): e47774. IF (2012): 4.3. doi: 10.1371/journal.pone.0047774
Di Pizio A, Laghezza A, Tortorella P, Agamennone M*. Probing the S1’ Site for the Identification of Non-Zinc-Binding MMP-2 Inhibitors. ChemMedChem 2013, 8(9): 1475-82. IF (2013): 3.3. doi: 10.1002/cmdc.201300186
Di Pizio A and Niv MY*. Promiscuity and selectivity of bitter molecules and their receptors. Bioorganic and Medicinal Chemistry 2015, 23(14): 4082-91. IF (2015): 3.2. doi: 10.1016/j.bmc.2015.04.025
Di Pizio A and Niv MY*. Computational Studies of Smell and Taste Receptors. Israel Journal of Chemistry 2014, 54: 1205-1218. IF (2014): 2.9. doi: 10.1002/ijch.201400027
Ferrucci A, Leboffe L, Agamennone M, Di Pizio A, Fiocchetti M, Marino M, Ascenzi P*, Luisi G*. Ac-tLeu-Asp-H is the minimal and highly effective human caspase-3 inhibitor: biological and in silico studies. Amino Acids 2015, 47(1):153-62. IF (2015): 3.5. doi: 10.1007/s00726-014-1855-3
Giustiniano M, Tortorella P, Agamennone M, Di Pizio A, Rossello A, Nuti E, Gomez-Monterrey I, Novellino E, Campiglia P, Vernieri E, Sala M, Bertamino A, Carotenuto A*. Amino acid derivatives as new zinc binding groups for the design of selective matrix metalloproteinase inhibitors. Journal of Amino Acids 2013: 178381. doi: 10.1155/2013/178381