We are pleased to announce three open Ph.D. positions in DFG funded research projects investigating the multifaceted role of the gut hormone secretin beyond the enteric system. We identified secretin as a key mediator of meal-induced thermogenesis in brown adipose tissue (BAT), impacting hunger and satiation (DOI: 10.1016/j.cell.2018.10.016). Contrary to previous beliefs, our research suggests a gut-BAT-brain axis, challenging the idea of secretin's central action in the brain. Our goal is to determine the relative contributions of central and direct effects of secretin by employing conditional knockout models. We will uncover afferent pathways of BAT-brain communication, including heat transfer, neuronal transmission or endocrine signaling. Our findings in humans underscore secretin's role in BAT activation, affecting both homeostatic and hedonic-driven food intake.