Fat metabolism
Mitochondria are the power plants in our cells. They convert the energy of carbohydrate, fat and protein into ATP (adenosine triphosphate). ATP is the energy currency in our cellular metabolism. It must be continuously formed for the maintenance of all vital processes. As fat storage in adipocytes increases, mitochondrial activity in adipocytes is reduced.
Selected publications
Fischer B, Schöttl T, Schempp C, Fromme T, Hauner H, Klingenspor M, Skurk T. Inverse relationship between body mass index and mitochondrial oxidative phosphorylation capacity in human subcutaneous adipocytes. Am J Physiol Endocrinol Metab. 2015 Aug 15;309(4):E380-7. doi: 10.1152/ajpendo.00524.2014.
Schöttl T, Kappler L, Fromme T, Klingenspor M. Limited OXPHOS capacity in white adipocytes is a hallmark of obesity in laboratory mice irrespective of the glucose tolerance status.
Mol Metab. 2015 Jul 15;4(9):631-42. doi: 10.1016/j.molmet.2015.07.001.
Schöttl T, Kappler L, Braun K, Fromme T, Klingenspor M. Limited mitochondrial capacity of visceral versus subcutaneous white adipocytes in male C57BL/6N mice. Endocrinology. Mar;156(3):923-33, 2015
Schöttl T, Klingenspor M. Boosting mitochondrial biogenesis in white adipocytes: A route towards improved insulin sensitivity? Mol Metab. 2013 Jul 10;2(3):128-9. doi: 10.1016/j.molmet.2013.07.002.