Hunger and Satiety
Adipocytes are the fat-storing cells in our body. They communicate with the brain via messenger substances (hormones) and sensory nerves. One of these messengers is leptin, which reports the level of our fat stores to the brain as a kind of fuel gauge.
Selected publications
Bolze F, Morath V, Bast A, Rink N, Schlapschy M, Mocek S, Skerra A, Klingenspor M. Long-acting PASylated leptin ameliorates obesity by promoting satiety and preventing hypometabolism in leptin-deficient Lepob/ob mice. Endocrinology. 2016 Jan;157(1):233-44. doi: 10.1210/en.2015-1519.
Bolze F, Rink N, Brumm H, Kühn R, Mocek S, Schwarz AE, Kless C, Biebermann H, Wurst W, Rozman J, Klingenspor M. Characterization of the melanocortin-4-receptor nonsense mutation W16X in vitro and in vivo. Pharmacogenomics J. 2013 Feb;13(1):80-93. doi: 10.1038/tpj.2011.43.
Tups A, Stöhr S, Helwig M, Barrett P, Krol E, Schachtner J, Mercer JG, Klingenspor M.
Seasonal leptin resistance is associated with impaired signalling via JAK2-STAT3 but not ERK, possibly mediated by reduced hypothalamic GRB2 protein. J Comp Physiol B. 2012 May;182(4):553-67. doi: 10.1007/s00360-011-0637-4.