Nutrition and energy balance
Dietary obesity is caused by a long-term positive energy balance. The increased caloric intake promotes an imbalance between energy intake and energy turnover. Excess energy is stored in adipose tissue. This simple equation is in fact complicated because, paradoxically, increased calorie intake also leads to increased energy consumption, and obese people consume more energy per day than people of normal weight. We are investigating the genetic and physiological causes for the development of a positive energy balance.
Scientific Collaborations
Prof. Dr. Hrabé de Angelis, Helmholtz-Zentrum München, German Mouse Clinic
Prof. Dr. Dirk Haller
Prof. Dr. Bernhard Küster
Prof. Dr. Hans Hauner
Prof. Dr. Hannelore Daniel
Selected Publications
Rozman J, Rathkolb B, Oestereicher MA, Schütt C, Ravindranath AC, Leuchtenberger S, Sharma S, Kistler M, Willershäuser M, Brommage R, Meehan TF, Mason J, Haselimashhadi H; IMPC Consortium, Hough T, Mallon AM, Wells S, Santos L, Lelliott CJ, White JK, Sorg T, Champy MF, Bower LR, Reynolds CL, Flenniken AM, Murray SA, Nutter LMJ, Svenson KL, West D, Tocchini-Valentini GP, Beaudet AL, Bosch F, Braun RB, Dobbie MS, Gao X, Herault Y, Moshiri A, Moore BA, Kent Lloyd KC, McKerlie C, Masuya H, Tanaka N, Flicek P, Parkinson HE, Sedlacek R, Seong JK, Wang CL, Moore M, Brown SD, Tschöp MH, Wurst W, Klingenspor M, Wolf E, Beckers J, Machicao F, Peter A, Staiger H, Häring HU, Grallert H, Campillos M, Maier H, Fuchs H, Gailus-Durner V, Werner T, Hrabe de Angelis M. Identification of genetic elements in metabolism by high-throughput mouse phenotyping. Nat Commun. 2018 Jan 18;9(1):288. doi: 10.1038/s41467-017-01995-2.
Kleinert M, Clemmensen C, Hofmann SM, Moore MC, Renner S, Woods SC, Huypens P, Beckers J, de Angelis MH, Schürmann A, Bakhti M, Klingenspor M, Heiman M, Cherrington AD, Ristow M, Lickert H, Wolf E, Havel PJ, Müller TD, Tschöp MH. Animal models of obesity and diabetes mellitus. Nat Rev Endocrinol. 2018 Mar;14(3):140-162. doi: 10.1038/nrendo.2017.161.
Kless C, Rink N, Rozman J, Klingenspor M. Proximate causes for diet-induced obesity in laboratory mice: a case study. Eur J Clin Nutr. 2017 Mar;71(3):306-317. doi: 10.1038/ejcn.2016.243.
Kübeck R, Bonet-Ripoll C, Hoffmann C, Walker A, Müller VM, Schüppel VL, Lagkouvardos I, Scholz B, Engel KH, Daniel H, Schmitt-Kopplin P, Haller D, Clavel T, Klingenspor M. Dietary fat and gut microbiota interactions determine diet-induced obesity in mice. Mol Metab. 2016 Oct 13;5(12):1162-1174. doi: 10.1016/j.molmet.2016.10.001.
Lohr K, Pachl F, Moghaddas Gholami A, Geillinger KE, Daniel H, Kuster B, Klingenspor M. Reduced mitochondrial mass and function add to age-related susceptibility toward diet-induced fatty liver in C57BL/6J mice. Physiol Rep. 2016 Oct;4(19). pii: e12988.
Kless C, Müller VM, Schüppel VL, Lichtenegger M, Rychlik M, Daniel H, Klingenspor M, Haller D. Diet-induced obesity causes metabolic impairment independent of alterations in gut barrier integrity. Mol Nutr Food Res. 2015 May;59(5):968-78. doi: 10.1002/mnfr.201400840.
Seyfarth K, Poschmann G, Rozman J, Fromme T, Rink N, Hofmann A, Wurst W, Stühler K, Klingenspor M. The development of diet-induced obesity and associated metabolic impairments in Dj-1 deficient mice. J Nutr Biochem. 2015 Jan;26(1):75-81. doi: 10.1016/j.jnutbio.2014.09.002.