In eukaryotes, the conjugation of the ubiquitinlike protein NEDD8 onto protein targets is an important post-translational modification. Little is known about the role of other deneddylating enzymes the role of neddylation and deneddylation of their substrates.
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Here we show that epidermal growth factor receptor (EGFR) inhibition by Gefitinib is counteracted by growth factors, notably FGF2, and we assessed the global molecular consequences of this resistance at the proteome and phosphoproteome level in A431 cells.
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Here, we used chemical proteomics to survey 235 clinical kinase inhibitors for their kinase selectivity and identified 24 drugs with submicromolar affinities for EPHA2.
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In this study, we compared tandem mass spectrometry (MS/MS) on MALDI-TOF nESI Orbitrap instruments with respect to their ability to identify phosphopeptides from complex proteome digests.
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The enzyme ferrochelatase (FECH) catalyzes the conversion of protoporphyrin IX into heme and was recently found to be an off-target of the BRAF inhibitor Vemurafenib, likely explaining the phototoxicity associated with this drug in melanoma patients. This raises the question of whether FECH binding…
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Bei der Akademischen Jahresfeier der Technischen Universität München (TUM) wurde bekannt gegeben, welche TUM-Nachwuchsforscher 2015 zu den Besten zählen. Mit dabei ist Master-Absolventin Jana Zecha vom Lehrstuhl für Proteomik und Bioanalytik am Wissenschaftszentrum Weihenstephan für Ernährung,…
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