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Technical University of Munich

Dr. Severin Lechner

Position: Postdoc
Room: 005
Category: Scientific Staff
Phone: 0 8161 714202
Email: severin.lechner[at]tum.de

Publications

2024

  • Chang, Yun-Chien; Gnann, Christian; Steimbach, Raphael R.; Bayer, Florian P.; Lechner, Severin; Sakhteman, Amirhossein; Abele, Miriam; Zecha, Jana; Trendel, Jakob; The, Matthew; Lundberg, Emma; Miller, Aubry K.; Kuster, Bernhard: Decrypting lysine deacetylase inhibitor action and protein modifications by dose-resolved proteomics. Cell Reports 43 (6), 2024, 114272 more…
  • Eckert, Stephan; Berner, Nicola; Kramer, Karl; Schneider, Annika; Müller, Julian; Lechner, Severin; Brajkovic, Sarah; Sakhteman, Amirhossein; Graetz, Christian; Fackler, Jonas; Dudek, Michael; Pfaffl, Michael W.; Knolle, Percy; Wilhelm, Stephanie; Kuster, Bernhard: Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics. Nature Biotechnology, 2024 more…
  • Schwalm, Martin P.; Dopfer, Johannes; Kumar, Adarsh; Greco, Francesco A.; Bauer, Nicolas; Löhr, Frank; Heering, Jan; Cano-Franco, Sara; Lechner, Severin; Hanke, Thomas; Jaser, Ivana; Morasch, Viktoria; Lenz, Christopher; Fearon, Daren; Marples, Peter G.; Tomlinson, Charles W. E.; Brunello, Lorene; Saxena, Krishna; Adams, Nathan B. P.; von Delft, Frank; Müller, Susanne; Stolz, Alexandra; Proschak, Ewgenij; Kuster, Bernhard; Knapp, Stefan; Rogov, Vladimir V.: Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets. Nature Communications 15 (1), 2024 more…

2023

  • Krumm, Johannes; Petrova, Elissaveta; Lechner, Severin; Mergner, Julia; Boehm, Hans-Henning; Prestipino, Alessandro; Steinbrunn, Dominik; Deline, Marshall L.; Koetzner, Lisa; Schindler, Christina; Helming, Laura; Fromme, Tobias; Klingenspor, Martin; Hahne, Hannes; Pieck, Jan-Carsten; Kuster, Bernhard: High-throughput screening and proteomic characterization of compounds targeting myeloid-derived suppressor cells. Molecular & Cellular Proteomics, 2023, 100632 more…
  • Lechner, Severin; Steimbach, Raphael R.; Wang, Longlong; Deline, Marshall L.; Chang, Yun-Chien; Fromme, Tobias; Klingenspor, Martin; Matthias, Patrick; Miller, Aubry K.; Médard, Guillaume; Kuster, Bernhard: Chemoproteomic target deconvolution reveals Histone Deacetylases as targets of (R)-lipoic acid. Nature Communications 14 (1), 2023 more…
  • Tüshaus, Johanna; Sakhteman, Amirhossein; Lechner, Severin; The, Matthew; Mucha, Eike; Krisp, Christoph; Schlegel, Jürgen; Delbridge, Claire; Kuster, Bernhard: A region‐resolved proteomic map of the human brain enabled by high‐throughput proteomics. The EMBO Journal, 2023 more…
  • Zecha, Jana; Bayer, Florian P.; Wiechmann, Svenja; Woortman, Julia; Berner, Nicola; Müller, Julian; Schneider, Annika; Kramer, Karl; Abril-Gil, Mar; Hopf, Thomas; Reichart, Leonie; Chen, Lin; Hansen, Fynn M.; Lechner, Severin; Samaras, Patroklos; Eckert, Stephan; Lautenbacher, Ludwig; Reinecke, Maria; Hamood, Firas; Prokofeva, Polina; Vornholz, Larsen; Falcomatà, Chiara; Dorsch, Madeleine; Schröder, Ayla; Venhuizen, Anton; Wilhelm, Stephanie; Médard, Guillaume; Stoehr, Gabriele; Ruland, Jürgen; Grüner, Barbara M.; Saur, Dieter; Buchner, Maike; Ruprecht, Benjamin; Hahne, Hannes; The, Matthew; Wilhelm, Mathias; Kuster, Bernhard: Decrypting drug actions and protein modifications by dose- and time-resolved proteomics. Science 380 (6640), 2023, 93-101 more…

2022

  • Glas, Carina; Naydenova, Eli; Lechner, Severin; Wössner, Nathalie; Yang, Liu; Dietschreit, Johannes C.B.; Sun, Hongyan; Jung, Manfred; Kuster, Bernhard; Ochsenfeld, Christian; Bracher, Franz: Development of hetero-triaryls as a new chemotype for subtype-selective and potent Sirt5 inhibition. European Journal of Medicinal Chemistry 240, 2022, 114594 more…
  • Lechner, Severin; Malgapo, Martin Ian P.; Grätz, Christian; Steimbach, Raphael R.; Baron, Agnes; Rüther, Patrick; Nadal, Simon; Stumpf, Carmen; Loos, Christina; Ku, Xin; Prokofeva, Polina; Lautenbacher, Ludwig; Heimburg, Tino; Würf, Vivian; Meng, Chen; Wilhelm, Mathias; Sippl, Wolfgang; Kleigrewe, Karin; Pauling, Josch K.; Kramer, Karl; Miller, Aubry K.; Pfaffl, Michael W.; Linder, Maurine E.; Kuster, Bernhard; Médard, Guillaume: Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nature Chemical Biology, 2022 more…
  • Steimbach, Raphael R.; Herbst-Gervasoni, Corey J.; Lechner, Severin; Stewart, Tracy Murray; Klinke, Glynis; Ridinger, Johannes; Géraldy, Magalie N. E.; Tihanyi, Gergely; Foley, Jackson R.; Uhrig, Ulrike; Kuster, Bernhard; Poschet, Gernot; Casero, Robert A., Jr.; Médard, Guillaume; Oehme, Ina; Christianson, David W.; Gunkel, Nikolas; Miller, Aubry K.: Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. Journal of the American Chemical Society 144 (41), 2022, 18861-18875 more…
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