2023
- Optimization of the Lead Compound NVP‐BHG712 as a Colorectal Cancer Inhibitor. Chemistry – A European Journal 29 (23), 2023 more…
2022
- A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer. Bioorganic Chemistry 119, 2022, 105505 more…
2021
- Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders. Journal of Medicinal Chemistry 64 (15), 2021, 10682-10710 more…
2020
- PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase. Nature Chemical Biology 16 (11), 2020, 1179-1188 more…
- Robust, reproducible and quantitative analysis of thousands of proteomes by micro-flow LC–MS/MS. Nature Communications 11 (1), 2020 more…
- Proteome activity landscapes of tumor cell lines determine drug responses. Nature Communications 11 (1), 2020 more…
- Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A. Nature Communications 11 (1), 2020 more…
- Heat and Pressure Resistance in Escherichia coli Relates to Protein Folding and Aggregation. Frontiers in Microbiology 11, 2020 more…
- Identification of molecular targets for the targeted treatment of gastric cancer using dasatinib. Oncotarget 11 (5), 2020, 535-549 more…
- Radiosensitization by kinase inhibition revealed by phosphoproteomic analysis of pancreatic cancer cells. Molecular & Cellular Proteomics, 2020, mcp.RA120.002046 more…
2019
- The formation of a camalexin-biosynthetic metabolon. The Plant Cell, 2019, tpc.00403.2019 more…
- Kinobeads: A Chemical Proteomic Approach for Kinase Inhibitor Selectivity Profiling and Target Discovery. Target Discovery and Validation: Methods and Strategies for Drug Discovery, 2019, 97--130 more…
- Chemoproteomic Selectivity Profiling of PIKK and PI3K Kinase Inhibitors. ACS Chemical Biology 14 (4), 2019, 655-664 more…
- CiRCus: A Framework to Enable Classification of Complex High-Throughput Experiments. Journal of Proteome Research 18 (4), 2019, 1486-1493 more…
2018
- Evaluation of promoter sequences for the secretory production of a Clostridium thermocellum cellulase in Paenibacillus polymyxa. Applied Microbiology and Biotechnology 102 (23), 2018, 10147-10159 more…
- NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. ChemMedChem 13 (16), 2018, 1629-1633 more…
- Increased Pancreatic Protease Activity in Response to Antibiotics Impairs Gut Barrier and Triggers Colitis. Cellular and Molecular Gastroenterology and Hepatology 6 (3), 2018, 370-388.e3 more…
2017
- Pharmacoproteomic characterisation of human colon and rectal cancer. Molecular Systems Biology 13 (11), 2017, 951 more…
- Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors. ChemMedChem 12 (12), 2017, 999-1011 more…
- The target landscape of clinical kinase drugs. Science 358 (6367), 2017, eaan4368 more…
2016
- Expression and Purification of EPHA2 Tyrosine Kinase Domain for Crystallographic and NMR Studies. ChemBioChem 17 (23), 2016, 2257-2263 more…
- Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs. ACS Chem Biol, 2016 more…
- Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. ACS Chemical Biology 11 (5), 2016, 1245-1254 more…
- Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1). Future Medicinal Chemistry 8 (13), 2016, 1537-1551 more…
- Identification of Highly Potent Protein Kinase C-Related Kinase 1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and in vitro Testing. ChemMedChem 11 (18), 2016, 2084-2094 more…
2015
- DENEDDYLASE1 Deconjugates NEDD8 from Non-Cullin Protein Substrates inArabidopsis thaliana. The Plant Cell 27 (3), 2015, 741-753 more…
- Optimized Chemical Proteomics Assay for Kinase Inhibitor Profiling. Journal of Proteome Research 14 (3), 2015, 1574-1586 more…
- Evaluation of Kinase Activity Profiling Using Chemical Proteomics. ACS Chemical Biology 10 (12), 2015, 2743-2752 more…
2014
- Probing SH2-domains using Inhibitor Affinity Purification (IAP). Proteome Science 12 (1), 2014, 41 more…
- New Affinity Probe Targeting VEGF Receptors for Kinase Inhibitor Selectivity Profiling by Chemical Proteomics. Journal of Proteome Research 13 (5), 2014, 2445-2452 more…
- A new chemical probe for quantitative proteomic profiling of fibroblast growth factor receptor and its inhibitors. Journal of Proteomics 96, 2014, 44-55 more…
2013
- ML3 Is a NEDD8- and Ubiquitin-Modified Protein. PLANT PHYSIOLOGY 163 (1), 2013, 135-149 more…