2024
- Exploring crop genomes: assembly features, gene prediction accuracy, and implications for proteomics studies. BMC Genomics 25 (1), 2024 more…
- Decrypting lysine deacetylase inhibitor action and protein modifications by dose-resolved proteomics. Cell Reports 43 (6), 2024, 114272 more…
- Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics. Nature Biotechnology, 2024 more…
- D6PK plasma membrane polarity requires a repeated CXX(X)P motif and PDK1-dependent phosphorylation. Nature Plants, 2024 more…
- Transport properties of canonical PIN-FORMED proteins from Arabidopsis and the role of the loop domain in auxin transport. Developmental Cell, 2024 more…
- A new mass analyzer shakes up the proteomics field. Nature Biotechnology, 2024 more…
- Thieno[3,2‐b]pyridine: Attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode. Angewandte Chemie International Edition, 2024 more…
- A Novel AMPK Inhibitor Sensitizes Pancreatic Cancer Cells to Ferroptosis Induction. Advanced Science, 2024 more…
- FBXL6 is a vulnerability in AML and unmasks proteolytic cleavage as a major experimental pitfall in myeloid cells. Leukemia, 2024 more…
- Inhibiting Hippo pathway kinases releases WWC1 to promote AMPAR-dependent synaptic plasticity and long-term memory in mice. Science Signaling 17 (834), 2024 more…
- AI-Assisted Processing Pipeline to Boost Protein Isoform Detection. In: Protein Bioinformatics. Springer US, 2024 more…
- Integrating multi‐omics data reveals energy and stress signaling activated by abscisic acid in Arabidopsis. The Plant Journal, 2024 more…
2023
- Unified workflow for the rapid and in-depth characterization of bacterial proteomes. Molecular & Cellular Proteomics, 2023, 100612 more…
- Proteomic meta-study harmonization, mechanotyping and drug repurposing candidate prediction with ProHarMeD. npj Systems Biology and Applications 9 (1), 2023 more…
- UHMK1 is a novel splicing regulatory kinase. Journal of Biological Chemistry 299 (4), 2023, 103041 more…
- CurveCurator: a recalibrated F-statistic to assess, classify, and explore significance of dose–response curves. Nature Communications 14 (1), 2023 more…
- A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases. eBioMedicine 89, 2023, 104456 more…
- Getting Ready for Large-Scale Proteomics in Crop Plants. Nutrients 15 (3), 2023, 783 more…
- Negative feedback regulation of MAPK signaling is an important driver of chronic lymphocytic leukemia progression. Cell Reports 42 (10), 2023, 113017 more…
- Multicenter Collaborative Study to Optimize Mass Spectrometry Workflows of Clinical Specimens. Journal of Proteome Research, 2023 more…
- An introduction to analytical challenges, approaches and applications in mass-spectrometry-based secretomics. Molecular & Cellular Proteomics, 2023, 100636 more…
- High-throughput screening and proteomic characterization of compounds targeting myeloid-derived suppressor cells. Molecular & Cellular Proteomics, 2023, 100632 more…
- Structural Basis for Highly Selective Class II Alpha Phosphoinositide-3-Kinase Inhibition. Journal of Medicinal Chemistry, 2023 more…
- Chemoproteomic target deconvolution reveals Histone Deacetylases as targets of (R)-lipoic acid. Nature Communications 14 (1), 2023 more…
- Illuminating phenotypic drug responses of sarcoma cells to kinase inhibitors by phosphoproteomics. Molecular Systems Biology, 2023 more…
- Discovery of Potent and Exquisitely Selective Inhibitors of Kinase CK1 with Tunable Isoform Selectivity. Angewandte Chemie 135 (11), 2023 more…
- Oktoberfest: Open‐source spectral library generation and rescoring pipeline based on Prosit. PROTEOMICS, 2023 more…
- Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors. Nature Chemical Biology, 2023 more…
- Regulation of BCMA By the Ubiquitin Proteasome System Enables Optimization of BCMA-Targeting Therapies in Multiple Myeloma. Blood 142 (Supplement 1), 2023, 3310-3310 more…
- Proteogenomic analysis reveals RNA as a source for tumor-agnostic neoantigen identification. Nature Communications 14 (1), 2023 more…
- Optimization of the Lead Compound NVP‐BHG712 as a Colorectal Cancer Inhibitor. Chemistry – A European Journal 29 (23), 2023 more…
- A region‐resolved proteomic map of the human brain enabled by high‐throughput proteomics. The EMBO Journal, 2023 more…
- Decrypting drug actions and protein modifications by dose- and time-resolved proteomics. Science 380 (6640), 2023, 93-101 more…
2022
- On the potential of micro-flow LC-MS/MS in proteomics. Expert Review of Proteomics 19 (3), 2022, 153-164 more…
- Novel, highly potent PROTACs targeting AURORA-A kinase. Current Research in Chemical Biology 2, 2022, 100032 more…
- Lactobacillus supports Clostridiales to restrict gut colonization by multidrug-resistant Enterobacteriaceae. Nature Communications 13 (1), 2022 more…
- Selective multi-kinase inhibition sensitizes mesenchymal pancreatic cancer to immune checkpoint blockade by remodeling the tumor microenvironment. Nature Cancer 3 (3), 2022, 318-336 more…
- Prosit-TMT: Deep Learning Boosts Identification of TMT-Labeled Peptides. Analytical Chemistry 94 (20), 2022, 7181-7190 more…
- Mass spectrometry-based draft of the mouse proteome. Nature Methods 19 (7), 2022, 803-811 more…
- Development of hetero-triaryls as a new chemotype for subtype-selective and potent Sirt5 inhibition. European Journal of Medicinal Chemistry 240, 2022, 114594 more…
- SIMSI-Transfer: Software-assisted reduction of missing values in phosphoproteomic and proteomic isobaric labeling data using tandem mass spectrum clustering. Molecular & Cellular Proteomics, 2022, 100238 more…
- Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes. Journal of Medicinal Chemistry 65 (19), 2022, 13264-13287 more…
- High temporal resolution proteome and phosphoproteome profiling of stem cell-derived hepatocyte development. Cell Reports 38 (13), 2022, 110604 more…
- Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. Nature Chemical Biology, 2022 more…
- A novel Cereblon E3 ligase modulator with antitumor activity in gastrointestinal cancer. Bioorganic Chemistry 119, 2022, 105505 more…
- Development of selective inhibitors of phosphatidylinositol 3-kinase C2α. Nature Chemical Biology, 2022 more…
- Plant Proteome Dynamics. Annual Review of Plant Biology 73 (1), 2022, 67-92 more…
- Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat. Molecular Metabolism 61, 2022, 101499 more…
- Epigenetic drug screening defines a PRMT5 inhibitor–sensitive pancreatic cancer subtype. JCI Insight 7 (10), 2022 more…
- The <scp>OTUD6B‐LIN28B‐MYC</scp> axis determines the proliferative state in multiple myeloma. The EMBO Journal 41 (20), 2022 more…
- Merits of Diazirine Photo-Immobilization for Target Profiling of Natural Products and Cofactors. ACS Chemical Biology, 2022 more…
- Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout. Journal of the American Chemical Society 144 (41), 2022, 18861-18875 more…
- Hippo-released WWC1 facilitates AMPA receptor regulatory complexes for hippocampal learning. Cell Reports 41 (10), 2022, 111766 more…
- Re-analysis of ProteomicsDB using an accurate, sensitive and scalable false discovery rate estimation approach for protein groups. Molecular & Cellular Proteomics, 2022, 100437 more…
- Posttranslational modification of the RHO of plants protein RACB by phosphorylation and cross-kingdom conserved ubiquitination. PLOS ONE 17 (3), 2022, e0258924 more…
- Linking post-translational modifications and protein turnover by site-resolved protein turnover profiling. Nature Communications 13 (1), 2022 more…
- Linking post-translational modifications and protein turnover by site-resolved protein turnover profiling. Nature Communications 13 (1), 2022 more…
- Proteomic profiling in cerebral amyloid angiopathy reveals an overlap with CADASIL highlighting accumulation of HTRA1 and its substrates. Acta Neuropathologica Communications 10 (1), 2022 more…
2021
- The emerging landscape of single-molecule protein sequencing technologies. Nature Methods 18 (6), 2021, 604-617 more…
- Cytomegalovirus subverts macrophage identity. Cell 184 (14), 2021, 3774-3793.e25 more…
- Robust Microflow LC-MS/MS for Proteome Analysis: 38 000 Runs and Counting. Analytical Chemistry 93 (8), 2021, 3686-3690 more…
- Identification of 7 000–9 000 Proteins from Cell Lines and Tissues by Single-Shot Microflow LC–MS/MS. Analytical Chemistry, 2021 more…
- Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells. Cell Stem Cell, 2021 more…
- Defining the carrier proteome limit for single-cell proteomics. Nature Methods 18 (1), 2021, 76-83 more…
- Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer. Cell Reports 36 (3), 2021, 109394 more…
- Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders. Journal of Medicinal Chemistry 64 (15), 2021, 10682-10710 more…
- Evaluation of Disposable Trap Column nanoLC–FAIMS–MS/MS for the Proteomic Analysis of FFPE Tissue. Journal of Proteome Research 20 (12), 2021, 5402-5411 more…
- The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma. Molecular Cell 81 (6), 2021, 1170-1186.e10 more…
- P01.05 Deciphering the function of the ubiquitin-proteasome-system in regulating the immune checkpoint protein B7-H3 (CD276) in non-small cell lung cancer. Poster Presentations, BMJ Publishing Group Ltd, 2021 more…
- High sensitivity glycomics in biomedicine. Mass Spectrometry Reviews 41 (6), 2021, 1014-1039 more…
- ProteomicsDB: toward a FAIR open-source resource for life-science research. Nucleic Acids Research, 2021 more…
- Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion. Nature Communications 12 (1), 2021 more…
- Systematic analysis of migration factors by MigExpress identifies essential cell migration control genes in non‐small cell lung cancer. Molecular Oncology, 2021 more…
- Mutations and variants of ONECUT1 in diabetes. Nature Medicine, 2021 more…
- SARS‐CoV‐2 infection remodels the host protein thermal stability landscape. Molecular Systems Biology 17 (2), 2021 more…
- Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV. Nature, 2021 more…
- Spectral Prediction Features as a Solution for the Search Space Size Problem in Proteogenomics. Molecular & Cellular Proteomics 20, 2021, 100076 more…
- Chemical Phosphoproteomics Sheds New Light on the Targets and Modes of Action of AKT Inhibitors. ACS Chemical Biology, 2021 more…
- Deep learning boosts sensitivity of mass spectrometry-based immunopeptidomics. Nature Communications 12 (1), 2021 more…
- PLK1‐dependent phosphorylation restrains EBNA2 activity and lymphomagenesis in EBV‐infected mice. EMBO reports 22 (12), 2021 more…
2020
- PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase. Nature Chemical Biology 16 (11), 2020, 1179-1188 more…
- Robust, reproducible and quantitative analysis of thousands of proteomes by micro-flow LC–MS/MS. Nature Communications 11 (1), 2020 more…
- Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription. Molecular Cell 77 (6), 2020, 1322-1339.e11 more…
- Wnt-driven LARGE2 mediates laminin-adhesive O-glycosylation in human colonic epithelial cells and colorectal cancer. Cell Communication and Signaling 18 (1), 2020 more…
- Combined proteomics/miRNomics of dendritic cell immunotherapy-treated glioblastoma patients as a screening for survival-associated factors. npj Vaccines 5 (1), 2020 more…
- PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells. Cell Reports 32 (4), 2020, 107957 more…
- Proteome activity landscapes of tumor cell lines determine drug responses. Nature Communications 11 (1), 2020 more…
- Dissecting the sequence determinants for dephosphorylation by the catalytic subunits of phosphatases PP1 and PP2A. Nature Communications 11 (1), 2020 more…
- Meltome atlas—thermal proteome stability across the tree of life. Nature Methods 17 (5), 2020, 495-503 more…
- Loss of the Fanconi anemia–associated protein NIPA causes bone marrow failure. Journal of Clinical Investigation 130 (6), 2020, 2827-2844 more…
- Mass-spectrometry-based draft of the Arabidopsis proteome. Nature 579 (7799), 2020, 409-414 more…
- Proteomic and transcriptomic profiling of aerial organ development in Arabidopsis. Scientific Data 7 (1), 2020 more…
- Identification of molecular targets for the targeted treatment of gastric cancer using dasatinib. Oncotarget 11 (5), 2020, 535-549 more…
- Proteomic and Metabolite Profiling Reveals Profound Structural and Metabolic Reorganization of Adipocyte Mitochondria in Obesity. Obesity 28 (3), 2020, 590-600 more…
- A series of novel aryl-methanone derivatives as inhibitors of FMS-like tyrosine kinase 3 (FLT3) in FLT3-ITD-positive acute myeloid leukemia. European Journal of Medicinal Chemistry 193, 2020, 112232 more…
- Radiosensitization by kinase inhibition revealed by phosphoproteomic analysis of pancreatic cancer cells. Molecular & Cellular Proteomics, 2020, mcp.RA120.002046 more…
- Data, Reagents, Assays and Merits of Proteomics for SARS-CoV-2 Research and Testing. Molecular & Cellular Proteomics 19 (9), 2020, 1503-1522 more…
2019
- High Heterogeneity of Multidrug-Resistant Enterobacteriaceae Fecal Levels in Hospitalized Patients Is Partially Driven by Intravenous β-Lactams. Antimicrobial Agents and Chemotherapy 64 (2), 2019 more…
- Quantification and discovery of sequence determinants of protein‐per‐mRNA amount in 29 human tissues. Molecular Systems Biology 15 (2), 2019 more…
- Prosit: proteome-wide prediction of peptide tandem mass spectra by deep learning. Nature Methods 16 (6), 2019, 509-518 more…
- Interactions between Transport Protein Particle (TRAPP) complexes and Rab GTP ases in Arabidopsis. The Plant Journal 100 (2), 2019, 279-297 more…
- Detection of plasmid-mediated colistin resistance, mcr-1 gene, in Escherichia coli isolated from high-risk patients with acute leukemia in Spain. Journal of Infection and Chemotherapy 25 (8), 2019, 605-609 more…
- Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms. Nature Chemistry 12 (2), 2019, 145-158 more…
- MOGSA: Integrative Single Sample Gene-set Analysis of Multiple Omics Data. Molecular & Cellular Proteomics 18 (8 suppl 1), 2019, S153-S168 more…
- The formation of a camalexin-biosynthetic metabolon. The Plant Cell, 2019, tpc.00403.2019 more…
- Challenges in Clinical Metaproteomics Highlighted by the Analysis of Acute Leukemia Patients with Gut Colonization by Multidrug-Resistant Enterobacteriaceae. Proteomes 7 (1), 2019, 2 more…
- Kinobeads: A Chemical Proteomic Approach for Kinase Inhibitor Selectivity Profiling and Target Discovery. Target Discovery and Validation: Methods and Strategies for Drug Discovery, 2019, 97--130 more…
- Chemoproteomic Selectivity Profiling of PIKK and PI3K Kinase Inhibitors. ACS Chemical Biology 14 (4), 2019, 655-664 more…
- Rebuilding core abscisic acid signaling pathways of Arabidopsis in yeast. The EMBO Journal 38 (17), 2019 more…
- ProteomicsDB: a multi-omics and multi-organism resource for life science research. Nucleic Acids Research, 2019 more…
- Characterization of Drug-Protein Interactions by Chemoproteomics. In: Proteomics for Biological Discovery. John Wiley & Sons, Inc., 2019 more…
- CiRCus: A Framework to Enable Classification of Complex High-Throughput Experiments. Journal of Proteome Research 18 (4), 2019, 1486-1493 more…
- PROTEOFORMER 2.0: Further Developments in the Ribosome Profiling-assisted Proteogenomic Hunt for New Proteoforms. Molecular & Cellular Proteomics 18 (8 suppl 1), 2019, S126-S140 more…
- A deep proteome and transcriptome abundance atlas of 29 healthy human tissues. Molecular Systems Biology 15 (2), 2019 more…
- TMT Labeling for the Masses: A Robust and Cost-efficient, In-solution Labeling Approach. Molecular & Cellular Proteomics 18 (7), 2019, 1468-1478 more…
- Proteomics Is Not an Island: Multi-omics Integration Is the Key to Understanding Biological Systems. Molecular & Cellular Proteomics 18 (8 suppl 1), 2019, S1-S4 more…
2018
- Dynamic Proteome Alteration and Functional Modulation of Human Saliva Induced by Dietary Chemosensory Stimuli. Journal of Agricultural and Food Chemistry 66 (22), 2018, 5621-5634 more…
- Protease signaling through protease activated receptor 1 mediate nerve activation by mucosal supernatants from irritable bowel syndrome but not from ulcerative colitis patients. PLOS ONE 13 (3), 2018, e0193943 more…
- Expanding the Use of Spectral Libraries in Proteomics. Journal of Proteome Research 17 (12), 2018, 4051-4060 more…
- Mining the Human Tissue Proteome for Protein Citrullination. Molecular & Cellular Proteomics 17 (7), 2018, 1378-1391 more…
- Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells. Nature Medicine 24 (3), 2018, 282-291 more…
- Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells. Nature Medicine 24 (4), 2018, 526--526 more…
- Adaptive Resistance to EGFR-Targeted Therapy by Calcium Signaling in NSCLC Cells. Molecular Cancer Research 16 (11), 2018, 1773-1784 more…
- NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. ChemMedChem 13 (16), 2018, 1629-1633 more…
- Increased Pancreatic Protease Activity in Response to Antibiotics Impairs Gut Barrier and Triggers Colitis. Cellular and Molecular Gastroenterology and Hepatology 6 (3), 2018, 370-388.e3 more…
- Peptide Level Turnover Measurements Enable the Study of Proteoform Dynamics. Molecular & Cellular Proteomics 17 (5), 2018, 974-992 more…
- ProteomeTools: Systematic Characterization of 21 Post-translational Protein Modifications by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS) Using Synthetic Peptides. Molecular & Cellular Proteomics 17 (9), 2018, 1850-1863 more…
2017
- Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening. Molecular Cell 67 (4), 2017, 711-723.e7 more…
- Effect of Astringent Stimuli on Salivary Protein Interactions Elucidated by Complementary Proteomics Approaches. Journal of Agricultural and Food Chemistry 65 (10), 2017, 2147-2154 more…
- Label-free quantitative proteome analysis of the surface-bound salivary pellicle. Colloids and Surfaces B: Biointerfaces 152, 2017, 68-76 more…
- Bacterial Cellulose Shifts Transcriptome and Proteome of Cultured Endothelial Cells Towards Native Differentiation. Molecular & Cellular Proteomics 16 (9), 2017, 1563-1577 more…
- Pharmacoproteomic characterisation of human colon and rectal cancer. Molecular Systems Biology 13 (11), 2017, 951 more…
- Chemoproteomics-Aided Medicinal Chemistry for the Discovery of EPHA2 Inhibitors. ChemMedChem 12 (12), 2017, 999-1011 more…
- N-Heterocyclic carbenes on close-packed coinage metal surfaces: bis-carbene metal adatom bonding scheme of monolayer films on Au, Ag and Cu. Chemical Science 8 (12), 2017, 8301-8308 more…
- The target landscape of clinical kinase drugs. Science 358 (6367), 2017, eaan4368 more…
- Target and identify: triazene linker helps identify azidation sites of labelled proteins via click and cleave strategy. Chem. Commun. 53 (87), 2017, 11929-11932 more…
- Targeted Diazotransfer Reagents Enable Selective Modification of Proteins with Azides. Bioconjugate Chemistry 28 (4), 2017, 913-917 more…
- Annotation of the Domestic Pig Genome by Quantitative Proteogenomics. Journal of Proteome Research 16 (8), 2017, 2887-2898 more…
- DENEDDYLASE1 Protein Counters Automodification of Neddylating Enzymes to Maintain NEDD8 Protein Homeostasis inArabidopsis. Journal of Biological Chemistry 292 (9), 2017, 3854-3865 more…
- Persistent inhibition of pore-based cell migration by sub-toxic doses of miuraenamide, an actin filament stabilizer. Scientific Reports 7 (1), 2017 more…
- Arabidopsis SH3P2 is an ubiquitin-binding protein that functions together with ESCRT-I and the deubiquitylating enzyme AMSH3. Proceedings of the National Academy of Sciences 114 (34), 2017, E7197-E7204 more…
- Optimized Enrichment of Phosphoproteomes by Fe-IMAC Column Chromatography. In: Methods in Molecular Biology. Springer New York, 2017 more…
- Hydrophilic Strong Anion Exchange (hSAX) Chromatography Enables Deep Fractionation of Tissue Proteomes. In: Methods in Molecular Biology. Springer New York, 2017 more…
- Lapatinib Resistance in Breast Cancer Cells Is Accompanied by Phosphorylation-Mediated Reprogramming of Glycolysis. Cancer Research 77 (8), 2017, 1842-1853 more…
- High pH Reversed-Phase Micro-Columns for Simple, Sensitive, and Efficient Fractionation of Proteome and (TMT labeled) Phosphoproteome Digests. In: Methods in Molecular Biology. Springer New York, 2017 more…
- ProteomicsDB. Nucleic Acids Research, 2017 more…
- The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity. Cell Reports 21 (13), 2017, 3846-3859 more…
- Quantitative Proteomics for the Comprehensive Analysis of Stress Responses ofLactobacillus paracaseisubsp.paracaseiF19. Journal of Proteome Research 16 (10), 2017, 3816-3829 more…
- Salivary Proteome Patterns Affecting Human Salt Taste Sensitivity. Journal of Agricultural and Food Chemistry 65 (42), 2017, 9275-9286 more…
- Preferential microRNA targeting revealed by in vivo competitive binding and differential Argonaute immunoprecipitation. Nucleic Acids Research 45 (17), 2017, 10218-10228 more…
- Wilhelm et al. reply. Nature 547 (7664), 2017, E23-E23 more…
- Trimodal Mixed Mode Chromatography That Enables Efficient Offline Two-Dimensional Peptide Fractionation for Proteome Analysis. Analytical Chemistry 89 (17), 2017, 8884-8891 more…
- Building ProteomeTools based on a complete synthetic human proteome. Nature Methods 14 (3), 2017, 259-262 more…
- PROCAL: A Set of 40 Peptide Standards for Retention Time Indexing, Column Performance Monitoring, and Collision Energy Calibration. PROTEOMICS 17 (21), 2017, 1700263 more…
2016
- Immunomodulatory drugs disrupt the cereblon–CD147–MCT1 axis to exert antitumor activity and teratogenicity. Nature Medicine 22 (7), 2016, 735-743 more…
- Expression and Purification of EPHA2 Tyrosine Kinase Domain for Crystallographic and NMR Studies. ChemBioChem 17 (23), 2016, 2257-2263 more…
- K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria. Immunity 45 (4), 2016, 761-773 more…
- Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs. ACS Chem Biol, 2016 more…
- Chemical Proteomics Reveals Ferrochelatase as a Common Off-target of Kinase Inhibitors. ACS Chemical Biology 11 (5), 2016, 1245-1254 more…
- Phosphoproteome Profiling Reveals Molecular Mechanisms of Growth-Factor-Mediated Kinase Inhibitor Resistance in EGFR-Overexpressing Cancer Cells. Journal of Proteome Research 15 (12), 2016, 4490-4504 more…
- Reduced mitochondrial mass and function add to age‐related susceptibility toward diet‐induced fatty liver in C57BL/6J mice. Physiological Reports 4 (19), 2016, e12988 more…
- moCluster: Identifying Joint Patterns Across Multiple Omics Data Sets. Journal of Proteome Research 15 (3), 2016, 755-765 more…
- Dimension reduction techniques for the integrative analysis of multi-omics data. Briefings in Bioinformatics 17 (4), 2016, 628-641 more…
- Translatomics combined with transcriptomics and proteomics reveals novel functional, recently evolved orphan genes in Escherichia coli O157:H7 (EHEC). BMC Genomics 17 (1), 2016 more…
- Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1). Future Medicinal Chemistry 8 (13), 2016, 1537-1551 more…
- MALDI-TOF and nESI Orbitrap MS/MS identify orthogonal parts of the phosphoproteome. PROTEOMICS 16 (10), 2016, 1447-1456 more…
- Identification of Highly Potent Protein Kinase C-Related Kinase 1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and in vitro Testing. ChemMedChem 11 (18), 2016, 2084-2094 more…
- Cell cycle-regulated PLEIADE/AtMAP65-3 links membrane and microtubule dynamics during plant cytokinesis. The Plant Journal 88 (4), 2016, 531-541 more…
- ERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer. Oncotarget, 2016 more…
- A bead-based western for high-throughput cellular signal transduction analyses. Nature Communications 7, 2016, 12852 more…
- Ethylene glycol improves electrospray ionization efficiency in bottom-up proteomics. Analytical and Bioanalytical Chemistry 409 (4), 2016, 1049-1057 more…
- Towards Understanding Male Infertility After Spinal Cord Injury Using Quantitative Proteomics. Molecular & Cellular Proteomics 15 (4), 2016, 1424-1434 more…
2015
- Novel Flp pilus biogenesis-dependent natural transformation. Frontiers in Microbiology 6, 2015 more…
- Semi-supervised Learning Predicts Approximately One Third of the Alternative Splicing Isoforms as Functional Proteins. Cell Reports 12 (2), 2015, 183-189 more…
- Inhibitor-based affinity probes for the investigation of JAK signaling pathways. PROTEOMICS 15 (17), 2015, 3066-3074 more…
- Chemical Proteomics Uncovers EPHA2 as a Mechanism of Acquired Resistance to Small Molecule EGFR Kinase Inhibition. Journal of Proteome Research 14 (6), 2015, 2617-2625 more…
- DENEDDYLASE1 Deconjugates NEDD8 from Non-Cullin Protein Substrates inArabidopsis thaliana. The Plant Cell 27 (3), 2015, 741-753 more…
- Optimized Chemical Proteomics Assay for Kinase Inhibitor Profiling. Journal of Proteome Research 14 (3), 2015, 1574-1586 more…
- Evaluation of Kinase Activity Profiling Using Chemical Proteomics. ACS Chemical Biology 10 (12), 2015, 2743-2752 more…
- A Scalable Approach for Protein False Discovery Rate Estimation in Large Proteomic Data Sets. Molecular & Cellular Proteomics 14 (9), 2015, 2394-2404 more…
- Optimized Plk1 PBD Inhibitors Based on Poloxin Induce Mitotic Arrest and Apoptosis in Tumor Cells. ACS Chemical Biology 10 (11), 2015, 2570-2579 more…
- Molecular mechanisms behind the antimicrobial activity of hop iso-α-acids in Lactobacillus brevis. Food Microbiology 46, 2015, 553-563 more…
2014
- De novodiscovery of phenotypic intratumour heterogeneity using imaging mass spectrometry. The Journal of Pathology 235 (1), 2014, 3-13 more…
- Disruption of the PRKCD–FBXO25–HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis. Nature Medicine 20 (12), 2014, 1401-1409 more…
- Phosphoramidates as Novel Activity-Based Probes for Serine Proteases. ChemBioChem 15 (8), 2014, 1106-1110 more…
- Ion Mobility Tandem Mass Spectrometry Enhances Performance of Bottom-up Proteomics. Molecular & Cellular Proteomics 13 (12), 2014, 3709-3715 more…
- Probing SH2-domains using Inhibitor Affinity Purification (IAP). Proteome Science 12 (1), 2014, 41 more…
- Investigating RET RTK Signaling Pathways Using an IAP-Based Activity-Profiling Approach. Journal of Proteome Research 13 (8), 2014, 3628-3634 more…
- New Affinity Probe Targeting VEGF Receptors for Kinase Inhibitor Selectivity Profiling by Chemical Proteomics. Journal of Proteome Research 13 (5), 2014, 2445-2452 more…
- A new chemical probe for quantitative proteomic profiling of fibroblast growth factor receptor and its inhibitors. Journal of Proteomics 96, 2014, 44-55 more…
- Quantitative proteome profiling of human myoma and myometrium tissue reveals kinase expression signatures with potential for therapeutic intervention. PROTEOMICS 15 (2-3), 2014, 356-364 more…
- A multivariate approach to the integration of multi-omics datasets. BMC Bioinformatics 15 (1), 2014, 162 more…
- Clec12a Is an Inhibitory Receptor for Uric Acid Crystals that Regulates Inflammation in Response to Cell Death. Immunity 40 (3), 2014, 389-399 more…
- A hydrodynamically optimized nano-electrospray ionization source and vacuum interface. The Analyst 139 (8), 2014, 1856 more…
- Mitotic arrest and slippage induced by pharmacological inhibition of Polo-like kinase 1. Molecular Oncology 9 (1), 2014, 140-154 more…
- Quantitative chemical proteomics reveals a Plk1 inhibitor-compromised cell death pathway in human cells. Cell Research 24 (9), 2014, 1141-1145 more…
- Comprehensive and Reproducible Phosphopeptide Enrichment Using Iron Immobilized Metal Ion Affinity Chromatography (Fe-IMAC) Columns. Molecular & Cellular Proteomics 14 (1), 2014, 205-215 more…
- Plant Cytokinesis Is Orchestrated by the Sequential Action of the TRAPPII and Exocyst Tethering Complexes. Developmental Cell 29 (5), 2014, 607-620 more…
- Tracking cancer drugs in living cells by thermal profiling of the proteome. Science 346 (6205), 2014, 1255784-1255784 more…
- Mass-spectrometry-based draft of the human proteome. Nature 509 (7502), 2014, 582-587 more…
- Systematic identification of the HSP90 regulated proteome. Mol Cell Proteomics., 2014 more…
- Auxin efflux by PIN-FORMED proteins is activated by two different protein kinases, D6 PROTEIN KINASE and PINOID. eLife 3, 2014 more…
2013
- Clinical response to chemotherapy in oesophageal adenocarcinoma patients is linked to defects in mitochondria. The Journal of Pathology 230 (4), 2013, 410-419 more…
- High-fat diet alters gut microbiota physiology in mice. The ISME Journal 8 (2), 2013, 295-308 more…
- Global Proteome Analysis of the NCI-60 Cell Line Panel. Cell Reports 4 (3), 2013, 609-620 more…
- Proteome wide purification and identification of O-GlcNAc modified proteins using Click chemistry and mass spectrometry. J Proteome Res., 2013 more…
- DMSO enhances electrospray response, boosting sensitivity of proteomic experiments. Nature Methods 10 (10), 2013, 989-991 more…
- ML3 Is a NEDD8- and Ubiquitin-Modified Protein. PLANT PHYSIOLOGY 163 (1), 2013, 135-149 more…
- Comparing immobilized kinase inhibitors and covalent ATP probes for proteomic profiling of kinase expression and drug selectivity. J Proteome Res., 2013 more…
- Comprehensive identification of proteins from MALDI imaging. Mol Cell Proteomics., 2013 more…
- MScDB: A Mass Spectrometry Centric Protein Sequence Database for Proteomics. J Proteome Res., 2013 more…
- A large synthetic peptide and phosphopeptide reference library for mass spectrometry–based proteomics. Nature Biotechnology 31 (6), 2013, 557-564 more…
- Characterization of a Chemical Affinity Probe Targeting Akt Kinases. Journal of Proteome Research 12 (8), 2013, 3792-3800 more…
- Characterization of a high field Orbitrap mass spectrometer for proteome analysis. PROTEOMICS 13 (17), 2013, 2552-2562 more…
- Measuring and Managing Ratio Compression for Accurate iTRAQ/TMT Quantification. J Proteome Res., 2013 more…
- Co-immunoprecipitation-based identification of putative BAX INHIBITOR-1-interacting proteins involved in cell death regulation and plant-powdery mildew interactions. Molecular Plant Pathology 14 (8), 2013, 791-802 more…
2012
- Affinity purification of proteins binding to kinase inhibitors immobilized on self-assembling monolayers. Methods Mol Biol. 795, 2012, 149-60 more…
- Quantitative mass spectrometry in proteomics. Analytical and Bioanalytical Chemistry 404 (4), 2012, 937-938 more…
- Quantitative mass spectrometry in proteomics: critical review update from 2007 to the present. Analytical and Bioanalytical Chemistry 404 (4), 2012, 939-965 more…
- SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma. Nature Cell Biology 15 (1), 2012, 72-81 more…
- MALDI Imaging Mass Spectrometry for In Situ Proteomic Analysis of Preneoplastic Lesions in Pancreatic Cancer. PLoS One. 7 (6), 2012, e39424 more…
- Discovery of O-GlcNAc-modified proteins in published large-scale proteome data. Mol Cell Proteomics., 2012 more…
- Discovery of O-GlcNAc-6-phosphate-modified proteins by re-analyzing large-scale phosphoproteomics data. Mol Cell Proteomics., 2012 more…
- Carbonyl-reactive tandem mass tags for the proteome-wide quantification of N-linked glycans. Anal Chem., 2012 more…
- Comprehensive proteome analysis in Cenococcum geophilum Fr. as a tool to discover drought-related proteins. Journal of Proteomics 75 (12), 2012, 3707-3719 more…
- A public-private partnership to unlock the untargeted kinome. Nature Chemical Biology 9 (1), 2012, 3-6 more…
- Software Tools for MS-Based Quantitative Proteomics: A Brief Overview. Methods Mol Biol. 893, 2012, 489-99 more…
- Phosphorylation site localization in peptides by MALDI MS/MS and the Mascot Delta Score. Anal Bioanal Chem. 402 (1), 2012, 249-60 more…
- Ultra-high intra-spectrum mass accuracy enables unambiguous identification of fragment reporter ions in isobaric multiplexed quantitative proteomics. PROTEOMICS 12 (9), 2012, 1328-1332 more…
- Mass Spectrometry-Based Proteomics in Preclinical Drug Discovery. Chemistry & Biology 19 (1), 2012, 72-84 more…
- A Simple and Effective Cleavable Linker for Chemical Proteomics Applications. Mol Cell Proteomics., 2012 more…
- Lactocepin secreted by lactobacillus exerts anti-inflammatory effects by selectively degrading proinflammatory chemokines. Cell Host Microbe. 11 (4), 2012, 387-96 more…
2011
- A Novel Two-Stage Tandem Mass Spectrometry Approach and Scoring Scheme for the Identification of O-GlcNAc Modified Peptides. J Am Soc Mass Spectrom. 22 (5), 2011, 931-42 more…
- Phosphotyrosine mediated protein interactions of the discoidin domain receptor 1. J Proteomics., 2011 more…
- Confident phosphorylation site localization using the Mascot Delta Score. Mol Cell Proteomics. 10 (2), 2011, M110.003830 more…
- Enterococcus faecalis Metalloprotease Compromises Epithelial Barrier and Contributes to Intestinal Inflammation. Gastroenterology., 2011 more…
- Quantitative chemical proteomics reveals new potential drug targets in head and neck cancer. Mol Cell Proteomics., 2011 more…
2010
- Bacterial production and functional characterization of the Fab fragment of the murine IgG1/ monoclonal antibody cmHsp70.1, a reagent for tumour diagnostics. Protein Engineering Design and Selection 23 (4), 2010, 161-168 more…
- Proteomics: a pragmatic perspective. Nat Biotechnol. 28 (7), 2010, 695-709 more…