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Dr. Mohammadali Khan Mirzaei
VICE HEAD OF THE RESEARCH UNIT
ORCID: 0000-0003-2801-4474
Dr. Mohammadali Khan Mirzaei's research integrates experimental and computational approaches to gain a deep understanding of complex phage-host interactions with the aim of developing next-generation therapeutics to treat multi-drug resistant infections and engineer the human microbiome. To achieve this, he develops and combines a diverse array of methodologies, including single-cell techniques, -omics approaches, metabolic labeling, and model systems.
Curriculum Vitae
Since 05/2022 Vice head of the research unit/ Team leader at the Institute of Virology, Helmholtz Zentrum München and Technical University of Munich, Germany
06/2019-05/2022 Senior postdoctoral researcher at the Institute of Virology, Helmholtz Zentrum München and Technical University of Munich, Germany
Research topic: Novel phage-based therapeutics for treating multi-drug resistant infections and engineering the human microbiome
05/2016-04/2019 Postdoctoral researcher at the Department of Microbiology and Imunology, McGill University, Montreal, Canada
Research topic: Phage-bacteria interactions in the human gut and their role in health and disease
12/2011-03/2016 Ph.D. in Molecular Genetics at the Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden
Thesis: The efficacy of bacterial viruses against multi-resistant Escherichia coli: from isolation to Pharmacology
09/2009-10/2011 M.Sc. in Molecular life sciences at the Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden
Thesis: Isolation and characterization of phages against multi-resistant Escherichia coli
Selected publications:
Khan Mirzaei M, and Maurice CF. (2017) Ménage à trois in the human gut: interactions between host, bacteria and phages. Nat Rev Microbiol. doi: 10.1038/nrmicro.2017.30
Khan Mirzaei M, et al. (2020). Bacteriophages regulate gut bacterial communities from stunted children in an age specific manner. Cell Host Microbe. doi: 10.1016/j.chom.2020.01.004
Khan Mirzaei M, and Deng L. (2022) New technologies for developing phage-based tools to manipulate the human microbiome. Trends Microbiol. doi: 10.1016/j.tim.2021.04.007.
Sinha A, Li Y, Khan Mirzaei, M, et al. (2022) Transplantation of bacteriophages from ulcerative colitis patients shifts the gut bacteriome and exacerbates the severity of DSS colitis. Microbiome. doi: 10.1186/s40168-022-01275-2
Ramaboli M, Ocvirk S, Khan Mirzaei M, et al. (2024). Diet Changes due to Urbanization in South Africa are Linked to Microbiome and Metabolome Signatures of Westernization and Colorectal Cancer. Nat Commun. doi: 10.1038/s41467-024-46265-0