The emergence and global spread of SARS-CoV-2 has resulted in the urgent need for an in-depth understanding of molecular functions of viral proteins and their interactions with the host proteome. Several individual omics studies have extended our knowledge of COVID-19 pathophysiology. Integration of…
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Due to its important roles in oncogenic signaling, AKT has been subjected to extensive drug discovery efforts leading to small molecule inhibitors investigated in advanced clinical trials. To better understand how these drugs exert their therapeutic effects at the molecular level, we combined…
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Explore global, steady-state proteomics and phosphoproteomics data for 125 cell lines using the ATLANTiC web application at atlantic.proteomics.wzw.tum.de!
Integrated analysis of genomes, transcriptomes, proteomes and drug responses of cancer cell lines (CCLs) is an emerging approach to uncover…
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Temperature influences the physiology of all living matter. Some organisms live in cold environments, most eukaryotes die when their inner temperature increases above 42 °C, but some species can survive even in hot springs. As most processes in life are regulated by proteins, we systematically…
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