Latest news from the Bartelt Lab
New paper on the impact of intermittent fasting in beta-cell maturation
25 Feb 2025
We are pleased to announce that our latest study has been published in Cell Reports. Our research demonstrates that chronic intermittent fasting impairs beta-cell maturation and function in pre-pubertal mice. This study was led by our co-shared Postdoctoral Researcher Leonardo Matta, under the supervision of Prof. Bartelt and Prof. Herzig at the Helmholtz Institute for Diabetes and Cancer.
Matta, L., Weber, P., Erener, S., Walth-Hummel, A., Hass, D., Bühler, L. K., Klepac, K., Szendroedi, J., Guerra, J., Rohm, M., Sterr, M., Lickert, H., Bartelt, A., & Herzig, S. (2025). Chronic intermittent fasting impairs β cell maturation and function in adolescent mice. Cell reports, 44(2), 115225. Advance online publication. doi.org/10.1016/j.celrep.2024.115225
New paper on oxidative stress and how protein recycling protects against cell death
15 Oct 2024
We are excited to share that our latest research has been published in Cell Death and Differentiation. Our study reveals that activating the NFE2L1-ubiquitin-proteasome system via DDI2 plays a crucial role in protecting against ferroptosis, a form of cell death.
Ofoghi, A., Kotschi, S., Lemmer, I. L., Haas, D. T., Willemsen, N., Bayer, B., Jung, A. S., Möller, S., Haberecht-Müller, S., Krüger, E., Krahmer, N., & Bartelt, A. (2024). Activating the NFE2L1-ubiquitin-proteasome system by DDI2 protects from ferroptosis. Cell death and differentiation, 10.1038/s41418-024-01398-z. Advance online publication. doi.org/10.1038/s41418-024-01398-z
New paper on IF1 in brown fat and thermogenesis
16 Sept 2024
We are excited to share that our latest research has been published in EMBO journal. Our research uncovers a novel mechanism that increases respiration and metabolic activity in brown adipocytes.
Brunetta, H. S., Jung, A. S., Valdivieso-Rivera, F., de Campos Zani, S. C., Guerra, J., Furino, V. O., Francisco, A., Berçot, M., Moraes-Vieira, P. M., Keipert, S., Jastroch, M., Martinez, L. O., Sponton, C. H., Castilho, R. F., Mori, M. A., & Bartelt, A. (2024). IF1 is a cold-regulated switch of ATP synthase hydrolytic activity to support thermogenesis in brown fat. The EMBO journal, 43(21), 4870–4891. https://doi.org/10.1038/s44318-024-00215-0
Newly Appointed Professor at the TUM School of Life Sciences
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Prof. Dr. Alexander Bartelt is newly appointed Professor of the Chair of Translational Nutritional Medicine at the TUM School of Life Sciences.
The EKFZ for Nutritional Medicine receives a Chair for Translational Nutritional Medicine
11 Sept 2024
The Else Kröner Fresenius Center for Nutritional Medicine is expanding: Starting in October 2024, Prof. Alexander Bartelt will take over the new Chair for Translational Nutritional Medicine at the TUM School of Life Sciences, aiming to translate innovative research approaches into practical applications.